Resveratrol_HistoryAlthough often mistakenly noted as originally isolated from Japanese knotweed (Polygonum capsidatum), a plant used in traditional folk medicines to treat many ailments, resveratrol was actually first isolated in 1940 from white hellebore roots by the Japanese scientist Michio Takaoka.5-6 Modern scientists began investigating resveratrol for its potential medicinal value in the 1970s after it was discovered grape vines produced resveratrol when infected with fungus.5 Further research determined that plants appeared to produce resveratrol in response to stress from injuries or diseases as a protective mechanism to limit the damage and extent of infection.5 Of the two isomer forms of resveratrol, trans-resveratrol is considered to exert more biological activity and is usually the more prevalent.7

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Molecular substances that have the same chemical
formula but with a different arrangement of atoms.

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