An animal study showed that topical pretreatment with resveratrol before UVB exposure significantly prevented known cancer-promoting changes in the skin, including:189

  • Generation of free radicals (such as H2O2) and inflammatory proteins
  • Proliferation of skin cancer cells
  • Activation of the pro-tumor protein survivin, which blocks normal cell death
  • Swelling of skin

Interestingly, topical treatment after UVB exposure produced the same protective benefits of pre-treatment to sun/UVB exposure. Both inhibited the number of skin tumors that occurred and delayed the onset of the malignant lesions.189

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