Studies show that resveratrol may be able to help prevent and counteract the effects of all too many beach days or tanning booth sessions. Too much sun exposure has been shown in numerous studies to be a primary factor in skin aging (e.g., wrinkles, hypo- and hyperpigmentation, and dryness). This is because the three types of ultraviolet (UV) radiation causes a number of negative biological effects in the skin:12

Type Wavelength Effects
UVA 320-400 nm
  • Penetrates the deepest
  • Causes DNA damage
  • Carcinogenic
  • Produces free radicals and oxidative damage (even more so than UVB)
  • Sagging skin from reduced collagen and elastin
  • Suppresses the immune system
UVB 280-320 nm
  • Causes DNA and RNA damage
  • Carcinogenic
  • Oxidative damage
  • Premature skin aging
  • Suppresses the immune system
UVC 200-280 nm
  • Highly mutagenic
  • Causes DNA damage

Although the skin has many protective mechanisms against UV damage, chronic exposure can overwhelm the skin’s natural defenses.12 Resveratrol can be a powerful ally to your skin, supporting its own natural defenses.

How It Works

Studies show that resveratrol’s anti-inflammatory, collagen-promoting, estrogenic, and antioxidant properties counteract the effects of aging and UV radiation.12,58 Current research into how resveratrol binds to skin cells suggests that resveratrol also helps promote skin healing factors and one of the body’s own powerful antioxidant enzymes (glutathione peroxidase).176

In personal care products, resveratrol has been shown to help improve the efficacy of another important skin antioxidant. Resveratrol is used to stabilize the antioxidant vitamin C in topical formulations since it tends to oxidize easily and lose its antioxidant properties.251

In addition to its antioxidant effects, resveratrol also appears to prevent mitochondrial dysfunction in skin cells related to skin damage from UVB.176 Even melanoma-causing UVA may be no match for resveratrol, according to some animal studies.57

Evidence of Benefit

In a clinical trial, an anti-wrinkle facial cream containing resveratrol and other botanicals was tested on 25 adult patients between the ages of 35 and 65. After six weeks of twice-daily topical use, all study participants showed significant improvement in facial wrinkles. None of the 15 women and 10 men reported only “no” or “fair” improvement, and 13 of the 25 reported “very good” to “excellent” improvement. The botanical source of resveratrol in the cream was listed as Vitis vinifera, the common grape vine plant. Other ingredients were aloe, sandalwood, tomato, kust, lemon, China Nora or lodh tree, Indian madder, turmeric, Nepal cardamom, licorice, Cuscus grass, valerian, and wheat bran.246

Industry-funded and independent studies demonstrate that resveratrol can counteract the aging effects of UV on skin in terms of loss of estrogen and decreased numbers and functioning of the skin cells that make collagen. Resveratrol has mild estrogenic effects, stimulates proliferation of fibroblast skin cells (naturally leading to increased production of collagen), and inhibits the enzyme activity that breaks down collagen.58

Resveratrol Studies Conducted by Manufacturers
Product Name Claims Evidence
Skin Beautiful Resveratrol Super Peptide Anti-Wrinkle Complex

“safe alternative to Botox”
  • Reduce wrinkle depth and volume by 50%
  • Skin smoothing
  • Counteracts inflammation with resveratrol
  • Increases collagen
  • 20% reduction in COX1, an inflammatory response enzyme.
  • A clinical study involving 6 women was conducted over 28 days. The study was double-blinded and placebo-controlled.252 With twice daily application of product photos and participant assessment showed improvement in wrinkles and complexion. Interestingly, one photo showed marked improvement in lightening an age spot.

Also used in “Trésor de Jeunesse” Anti-Ageing Cream “Grapevine Extract from the wine region of Bordeaux”
  • Decrease number of wrinkles up to 71%
  • Diminish wrinkle depth by up to 77%
  • 55% increase in SIRT-1 expression compared to control.
  • In a clinical test involving 20 women using 3% RESVERATROX® cream, 80% noticed a significant reduction in wrinkles. Photo of one participant showed dramatic improvement in 56 days.
Caudalie Pulpe Vitaminée “100% antioxidant cocktail”

Caudalie Premier Cru “Inspired by the finest vintages”
  • Diminishes fine lines
  • Evens out skin tone
  • Protects skin from free radicals
  • Patented form of resveratrol stabilized with lipophiles
  • Lab tests demonstrated increased collagen and elastin production, causing skin thickness to double in six days to visibly firmer skin.
Disclaimer: This website is not intended to replace professional consultation, diagnosis, or treatment by a licensed physician. If you require any medical related advice, contact your physician promptly. Information at is exclusively of a general reference nature. Do not disregard medical advice or delay treatment as a result of accessing information at this site.
Based on wavelength.
Aloe vera, known for its anti-inflammatory and antioxidant properties.
Santalum album, often used as a fragrance in cosmetics and soaps.
Solanum lycopersicum, known to have potent antioxidant effects
Saussurea lappa, shown to have antioxidant and anti-inflammatory properties;
also used as a fragrance.
Citrus limon, a strong antioxidant.
Symplocos racemosa, which has anti-inflammatory properties.
Rubia cordifolia, shown to possess antioxidant properties and traditionally
used in an Ayurvedic anti-inflammatory formulation.
Curcuma longa, known for its immune-boosting and antioxidant effects;
also inhibits the enzyme that breaks down collagen.
Amomum subulatum, an antioxidant that also increases natural
antioxidant enzymes.
Glycyrrhiza glabra, known to have antioxidant properties.
Vetiveria zizanioides, often used in aromatherapy and topically for
stress relief and as an insect repellent.
Valeriana wallichii, traditionally used not only for insomnia but
also to treat chronic skin conditions
Triticum sativum, reportedly useful in inflammatory skin conditons.

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