Resveratrol may help prevent or relieve diabetic neuropathy by improving blood flow and reducing inflammation.

Nerve damage (neuropathy) caused by diabetes is due to oxidative stress and pro-inflammatory conditions related to excess blood glucose.137 Resveratrol’s powerful antioxidant and anti-inflammatory properties have been shown to help relieve the pain associated with neuropathy, and may even be able to reverse some of the nerve damage.21-22

Although fairly common, risk factors include genetic predisposition, smoking, alcohol abuse, and immune system dysfunction. There are four types of diabetic neuropathy, which can cause an array of symptoms:138

  • Peripheral. Pain, numbness, tingling or burning feelings in the extremities, most commonly the legs and feet; muscle weakness; ulcers and other serious foot problems.
  • Autonomic. Digestive, urinary, and cardiovascular problems related to damaged nerve fibers; erectile dysfunction; sexual difficulties in women; inability to regulate heart rate, blood pressure, body temperature, or adjust eyes to light conditions.
  • Radiculoplexus. Affects nerves close to hips, shoulders, and abdomen rather than nerve ends; weakened thigh muscles; severe pain in hips, thighs, and buttocks; abdominal swelling; difficulty standing up from sitting.
  • Mononeuropathy. Sudden severe pain from damage to one nerve; Bell’s palsy; Carpal tunnel syndrome; pain in localized area behind one eye, shin, foot, thigh, or abdomen.

Neuropathy can be disabling and even fatal for some diabetics.138 In animal studies, resveratrol effectively decreased expression of various inflammatory proteins (i.e., COX-2 and TNF-α) that have been linked to diabetic neuropathy.137 Other studies confirm that resveratrol alleviated diabetic neuropathic pain, including that stimulated by heat or cold.21

In combination with another inhibitor , resveratrol also helped repair blood flow and nerve function in diabetic rats. The resveratrol combination also significantly reversed some of the damaging changes due to accumulation of PARP, a protein known to play an important role in the development of diabetic neuropathy.22,139

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Paralysis on one side of face; usually subsides.
Nerve damage in hand and wrist caused by compression of nerve.

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